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AAS Anabolics - The Story

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AAS Anabolics - The Story

Post by Canuck Singh on Mon Mar 08, 2010 2:31 am

Left Ventricular Function
Androgenic anabolic steroid use has been proposed to be responsible for some instances of heart attack and sudden cardiac death especially since the media hyped the death of two young male bodybuilders that were reported to be using these drugs.

This case study of the cardiac findings of both deaths tried to establish a relationship between anabolic steroids and cardiac death. However, one autopsy revealed normal coronary arteries. In the second, the only abnormality that could be detected (a segmentation of myocardial cells at the intercalated disc level was observed in the non-injured region) was not linked in any way to use of anabolic steroids. No other pathologic findings in the heart or other organs were found. The urine in both subjects contained the metabolites of nortestosterone and stanozolol.

The doctors concluded that the myocardial infarction that each bodybuilder suffered could not be linked to anabolic steroid use, bodybuilding, or a combination of both. Both incidences lacked any evidence of a cause-effect relationship. The histologic findings in these two cases and the few others reported in medical literature are nonspecific and do not prove evidence of cardiac toxicity from anabolic steroid use.

Ref: Arch Pathol Lab Med. 125(2):253-5, 2001.

Cont...
The media has linked anabolic steroid use in athletes to heart attacks, cardiac disease and other cardiovascular problems. However, until now there has been no clinical evidence to confirm or deny this.

A recent study by the Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia, has shown that there is no difference in heart size or function between a group of bodybuilders who use steroids and a group who don't.

This study examined arterial and cardiac structure and function in 20 male bodybuilders, 10 of whom were using anabolic-androgenic steroids and 10 who said they had never used steroids. Serum lipid and hormone levels were assessed as well as various dimensions of artery and heart ventricle thickness and function. Heart function in the bodybuilders was also compared to a group of non-exercising (sedentary) individuals.

The steroid using bodybuilders demonstrated all the undesirable serum lipid and hormone profile characteristic of long term steroid use, such as significantly decreased high-density lipoprotein cholesterol (the good cholesterol), as well as reduced **** hormone globulins, testosterone and gonadotrophin levels. However, all cardiac responses revealed no difference between drug using and non-drug using bodybuilders.

In fact, both groups of bodybuilders exhibited aspects of a stronger, healthier heart than their non-training counterparts (such as higher carotid intima-media thickness and lower dilation responses to endothelium-dependent and independent assessments).

The researchers concluded that the use of anabolic-androgenic steroids is not associated with significant abnormalities of arterial heart structure or function.

Ref: J Am Coll Cardiol 2001 Jan;37(1):224-30

Androgen Receptors:
Androgenic, anabolic steroids (produced within the body or artificially introduced) exert their powerful growth effects by binding to muscle cells via specific androgen receptors on muscle cells. These cell receptors are like "locks" and recognize anabolic steroids as the 'key" that fits and binds to the site. It is clear that the more androgen receptors a muscle fibre possesses, the greater the capacity it has for growth.

Researchers from Sweden's Umea University investigated whether long-term strength training and/or self-administration of androgenic-anabolic steroids changes the number and content of these steroid receptors in human muscle. Muscle biopsy samples were taken from the vastus lateralis (thigh) and trapezius (upper back) muscles of eight high-level power-lifters; nine high-level power-lifters who used anabolic steroids; and six untrained subjects. After the fibres were stained and analysed.

It was revealed that the proportion of androgen receptors per fibre cross-section was higher in the upper back muscles than in the thigh in all groups of men. That's interesting, as it implies that men's upper back muscles have greater affinity for muscle growth than their leg muscles. Results also revealed that androgen receptor concentrations in the upper back muscles were higher in the drug-free lifters than the untrained individuals! That means weight training actually increases the number of anabolic receptors in muscle!

However, the power-lifters who used anabolic steroids had the highest concentration of androgen receptors in their muscles. Interestingly, in the thigh muscle, there were no differences in androgen receptor content between drug-using and drug-free lifters. It appears that androgen content differs greatly between muscle groups with the human body.

Self-administration of androgenic-anabolic steroids combined with resistance training will increase the concentration of androgen receptors. However, a great finding for natural bodybuilders is that heavy weight training alone does a great job of enhancing the number of anabolic receptors in muscle. More androgen receptors in muscle means increase potential for muscle growth.

Ref+ Histochem Cell Biol. 113(1):25-9,2001

Loose laws in India - or lack thereof

Across most cities in India you can walk into a gym and buy the steroids of your choice, no problem. The gym instructors will even help you!

A recent raid by the Directorate of Revenue Intelligence (DRI) on importers of food supplements has uncovered a “well-oiled” racket in this country. The importers were caught smuggling an array of anabolic steroids from Thailand into India, supplying them to gyms in the major cities such as Delhi, Jaipur and Bangalore.

One major newspaper in India claims to have visited some fitness centers and found the abuse was not only rampant but the gyms were also very upfront about the business. The gym and staff openly promote the sale of food supplements and “bodybuilding medicines” that are “expensive but amazingly effective” to hundreds of skinny teenagers that frequent these facilities in the desire of achieving bulging biceps and a six-pack.

By the way, a gym pushing anabolic steroids is illegal in this country and these drugs do cause serious side-effects in teenagers.

Law enforcement authorities concede that laws controlling the open sale of such drugs are not strict. Also, there is no regulatory framework to monitor the activities of these gyms. The punishment for smuggling steroids is at worst, a monetary penalty.

Source: Hindustan Times – India
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Re: AAS Anabolics - The Story

Post by Canuck Singh on Mon Mar 08, 2010 2:31 am

For Educating yourself about the veil behind Steroids:

See here: http://video.google.com/videoplay?docid=-2670591054851050035

[gvideo]http://video.google.com/videoplay?docid=-2670591054851050035[/gvideo]

I am allowing these previews here for education purposes:


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Re: AAS Anabolics - The Story

Post by Canuck Singh on Mon Mar 08, 2010 2:31 am

Most people will associate the words “anabolic steroids” with elite athletes, sensational drug scandals and cheating.

However, according to a recent report involving the largest sample group to date; the majority of (anabolic) steroid users are not athletes. These people do not aspire to win world titles or Olympic gold medals. They don’t even compete in organized competition.

According to this scientific survey, published last month in a leading sports science journal, the typical anabolic steroid user is around 30 years old, well-educated, and earning an above-average income in a white-collar occupation.

This report concluded that the majority of non-medical anabolic steroid users are just regular people that want to build muscle, get lean and improve their physical attractiveness.

Other significant but less highly ranked factors included:
- increased confidence, improved mood and attraction

The authors suggest that steroid users don’t fall into the same category as abusers of narcotics and other illicit drugs – steroid users are “different”.?

According to the report, most steroid users follow carefully planned drug regimens in conjunction with a healthy diet, ancillary drugs and exercise. With these people, everything is strategically planned to “maximize benefits and minimize harm” - behavior that is directly opposite to the spontaneous and haphazard approach seen in abusers of psychotropic drugs.

I agree, most bodybuilders that use anabolic steroids hardly exhibit the drug-hooked, out-of-control “junkie” behavioral patterns the public usually associates with drug abuse and addiction.

However, I’m not sure where the researchers found such a large group of virtuous souls to complete this survey.
--------------------------------------------------------------------------------------------------------------------------------------------
Here is a first hand story of the experience:

I’ve worked with hundreds of bodybuilders over the years. Many have used drugs. Lots of drugs, and I could count on one hand the amount that took a single step to “minimize harm,” let alone any “strategic planning”. Heck, I couldn’t get most of them to go for a blood test.

Just for a moment, let’s just give the researchers the benefit of doubt that they managed to flesh out such a substantial number of highly-organized, health-conscious bodybuilders among the zoo of people that regularly frequent the gym.

After reading the conclusions of this report you’d almost be forgiven for thinking that taking the juice to get big was a benign and almost virtuous endeavor.

I’m neither pro or anti anabolic steroids - I believe any individual should be allowed to put anything they want into their body so long as it doesn’t affect anyone else. Everyone should be allowed to be a free individual to make their own choices.

Setting the obvious legality issues aside for one moment, I still don’t believe that non-medical anabolic steroid use (by healthy people) is a “cool” thing to do. It’s not even an “okay” thing to do.

I’ll explain why.

Using steroids won’t kill you. Heck, it probably won’t even make you sick. However, relying on the juice to build your muscle is not as benign as the whacked writers in the muscle mags try to make you believe.

* Firstly, many aspects of muscle metabolism and growth are controlled by the classic steroid-hormone binding mechanism. Both anabolic and catabolic hormones (the hormones that breakdown muscle tissue) exert their effects by binding to a cell membrane-receptor. Once attached, they activate a receptor complex so that the hormone can enter the nucleus and bind specific response elements on DNA to act directly at the genetic level. This is how all hormones both natural and artificial alter the production (transcription and subsequent translation) of specific proteins in cells. This is what ultimately influences results from exercise.

People that use anabolic steroids must use higher doses than physiological (normal) levels. That’s what ensures the benefit. However, these doses only stimulate growth via the previously mentioned process, for a short period of time. After this, the artificially introduced anabolic steroid exerts its effects mostly by attaching to (and blocking) cortisol receptors.

Even after just a few short cycles, muscles and other tissues express more and more cortisol receptors in an effort to keep a natural balance.

Higher and higher doses are required each steroid cycle just to provide the same anabolic effect.

When a person stops using anabolic steroids, their muscles contain an abnormally high level of cortisol receptors. There is no way around this.

Therefore, along with the suppression of their own natural production of anabolic hormones, the former steroid user also has to contend with a higher than normal number of cortisol receptors. The end result of going off the juice is always the loss of a substantial amount of hard earned muscle. Just as the saying goes, if you want to dance, you’ve gotta pay the band!

For this reason alone, steroids are an extremely poor solution to a lifelong pursuit. However, there is another problem.

Unfortunately, they mask the training and nutrition mistakes that most people make.

The gains come much easier. Therefore, most users don’t bother with learning about the right nutritional approach to building muscle or how to structure an effective exercise program that fits in with a 50 hour work week, the spouse and kids.

Some bodybuilders get so hooked by the gains and the powerful feeling from steroids that they can’t stand being in the gym when they’re not using. Even the pro bodybuilders find it real tough to train when they’re not on the juice. I’ve got to admit, it would be tough to focus on training when you know that no matter what, you’re getting smaller, weaker and fatter.

These are the psychological consequences of anabolic steroid abuse and they are far more damaging than any of the physical side-effects the medical profession tries to scare athletes about.

Here is the real shame; all the scientific research shows that no other type of exercise provides as many direct health benefits as weight training. Bodybuilding without drugs is the healthiest past-time a person can devote their time to.

Based on the physiological and psychological ramifications I’ve highlighted, the use of anabolic steroids among healthy people can wreck the healthiest, most beneficial past-time a person can participate in.

Sure, most people that use anabolic drugs are not elite athletes, they may never enter a competitive area. They can never be accused of cheating fellow competitors and the respective governing sports organization. However, most healthy people that take anabolic steroids will never admit that they are cheating one very, very important entity….themselves.
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